反应详情

To 100 ml. of mechanically stirred, refluxing dry ethyl acetate was introduced a steady flow of phosgene gas followed by the dropwise addition of 22.4g. N-2-phenoxyethyl-N-propylamine in 100 ml. dry ethyl acetate over a period of 45 minutes. On completion of the addition, the reaction mixture was boiled under reflux with stirring, whilst continuing the flow of phosgene for a further three hours. The solvent was removed on the steam bath, the last traces being extracted under vacuum to give N-2-phenoxyethyl-N-propylcarbamoyl chloride.

1. additionfollowed by the dropwise addition of 22.4g
2. additionOn completion of the addition
3. temperatureunder reflux
4. stirringwith stirring
5. customfor a further three hours
6. customThe solvent was removed on the steam bath
7. extractionthe last traces being extracted under vacuum