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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 262804Generated: October 30, 2026

Ethyl pyruvate → Ibuprofen, (+-)-

https://huagongshe.com/reaction/262804

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl pyruvateHCID 12041—
Reactant3-(2-Methylpropyl)cyclohexan-1-oneHCID 12528502—
ProductIbuprofen, (+-)-HCID 3672—

Reaction Steps

The process according to claim 8, by which 3-isobutyl-cyclohexanone and ethyl pyruvate are condensed without solvent and the condensate formed is heated at 220°-230° C. to give p-isobutyl-hydratropic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04154962
Source datasetuspto-grants-1979_05
ORD IDord-95b8735e14f84679ad5340ee25ef77f9
Source noteuspto-grants-1979_05