Ethyl pyruvate → Ibuprofen, (+-)-

HRID 262804Notes

Reaction equation

HRID 262804 reaction equation
[CH2:1]([CH:5]1[CH2:10][CH2:9][CH2:8][C:7](=O)[CH2:6]1)[CH:2]([CH3:4])[CH3:3].[C:12]([O:17]CC)(=[O:16])[C:13]([CH3:15])=O>>[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:13]([CH3:15])[C:12]([OH:17])=[O:16])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 12041Ethyl pyruvateHCID 125285023-(2-Methylpropyl)cyclohexan-1-one

Product 1

HCID 3672Ibuprofen, (+-)-

Procedure

The process according to claim 8, by which 3-isobutyl-cyclohexanone and ethyl pyruvate are condensed without solvent and the condensate formed is heated at 220°-230° C. to give p-isobutyl-hydratropic acid.

Workup

  1. customcondensed without solvent
  2. customthe condensate formed
  3. temperatureis heated at 220°-230° C.

Sources & evidence

ORD record
ord-95b8735e14f84679ad5340ee25ef77f9
Source dataset
uspto-grants-1979_05
Patent number
US04154962

Reaction notes

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