Benzene → HCID 13020861, compound

Participants

Reaction Steps

50 g of 17β-hydroxy-1α-methyl-5α-androstan-3-one were heated at reflux in 1000 ml of absolute benzene, 125 ml of ethylenegycol and 1.25 g of p-toluenesulphonic acid for 7 hours while stirring under a water separator. The solution was then diluted with ether, washed with sodium hydrogen carbonate solution and water, dried and evaporated to dryness. 55 g of 3,3-ethylenedioxy-17β-hydroxy-1α-methyl-5α-androstane were obtained.

Provenance & Evidence