Methyl iodide → HCID 21317820, compound

HRID 262997Notes

Reaction equation

HRID 262997 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]2[CH:13]3[CH2:14][CH2:15][CH2:16][CH2:17][CH:12]3[O:11][N:10]2[CH3:18])[CH:6]=[CH:7][CH:8]=1.[CH3:19][I:20]>O1CCCC1>[I-:20].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]2[CH:13]3[CH2:14][CH2:15][CH2:16][CH2:17][CH:12]3[O:11][N+:10]2([CH3:19])[CH3:18])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 21317850HCID 21317850, compound

Product 1

HCID 21317820HCID 21317820, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Crude octahydro-3-(m-methoxyphenyl)-2-methyl-1,2-benzisoxazole (15 g.) in tetrahydrofuran (120 ml.) was treated with an excess of methyl iodide (15 ml.). A crystalline solid began to separate almost immediately. After 12 hours the precipitate was filtered and washed with tetrahydrofuran to give the analytically pure product, m.p. 165° with decomposition.

Workup

  1. customto separate almost immediately
  2. filtrationAfter 12 hours the precipitate was filtered
  3. washwashed with tetrahydrofuran
  4. customto give the analytically pure product, m.p. 165° with decomposition

Sources & evidence

ORD record
ord-d790d80879ee44e4b6823ecf2ff8ff3f
Source dataset
uspto-grants-1979_05
Patent number
US04155935

Reaction notes

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