反应详情

温度

20 °C

7 g of potassium carbonate and 8.9 g of O,O-diethyl chlorothiophosphate were added to a solution of 10.9 g of 2,5-dicarbomethoxy-3-hydroxy-thiophene in 500 ml of acetone and the mixture was stirred for 15 hours at 20° C. and was then filtered. The filtrate was evaporated to dryness and the residue was empasted with a 10-1 petroleum ether-isopropyl ether mixture. The mixture was vacuum filtered and the precipitate was crystallized from ethanol to obtain 8.5 g of 2,5-dicarbomethoxy-3-(diethoxythiophosphoryloxy)-thiophene melting at 50° C.

1. filtrationwas then filtered
2. customThe filtrate was evaporated to dryness
3. filtrationfiltered
4. customthe precipitate was crystallized from ethanol