反应详情

温度

100 °C

A mixture of 67 g (0.520 mol) of p-chlorophenol and 29.5 g (0.520 mol) of KOH pellets is heated to 100° C. for 2 hours under a pressure of about 5 mm Hg. Thereafter 117 g (0.625 mol) of p-bromoanisole and 1 g of copper powder are added and the mixture is then heated to about 220°-230° C. for 5 hours. The cooled reaction mixture is taken up in diethyl ether and after removing the inorganic salts by filtration the filtrate is washed with 2 N sodium hydroxide solution and with water. The solvent is driven off under reduced pressure, drying is carried out with sodium sulphate and 133 g of an orange-coloured oil are obtained. Purification of this oil by distillation under reduced pressure given 70 g of a white crystalline mass which is insoluble in water.

1. temperaturethe mixture is then heated to about 220°-230° C. for 5 hours
2. customThe cooled reaction mixture
3. customafter removing the inorganic salts
4. filtrationby filtration the filtrate
5. washis washed with 2 N sodium hydroxide solution and with water
6. customdrying
7. customare obtained
8. customPurification of this oil
9. distillationby distillation under reduced pressure