反应详情

A solution of 3.78 g (0.0500 mol) of chloroacetonitrile in 10 ml of anhydrous ethanol is run over the course of 20 minutes into a solution of 1.04 g (0.0453 mol) of sodium and 10 g (0.0453 mol) of p-(p-chlorophenoxy)-phenol in 50 ml of anhydrous ethanol and the mixture is then heated to the reflux temperature for 4 hours. It is evaporated to dryness under reduced pressure and the residue is dissolved in diethyl ether, which is washed with water and with dilute sodium hydroxide solution. After drying over dry sodium sulphate and evaporating the solvent from the organic phase, 12 g of an orange-coloured oil are obtained. Purification of this oil by distillation under reduced pressure gives 9.5 g of a limpid pale yellow oil which is insoluble in water.

1. temperaturethe mixture is then heated to the reflux temperature for 4 hours
2. customIt is evaporated to dryness under reduced pressure
3. dissolutionthe residue is dissolved in diethyl ether
4. washwhich is washed with water and with dilute sodium hydroxide solution
5. dry with materialAfter drying over dry sodium sulphate
6. customevaporating the solvent from the organic phase, 12 g of an orange-coloured oil
7. customare obtained
8. customPurification of this oil
9. distillationby distillation under reduced pressure