反应详情

A suspension of 5.37 g (0.0772 mol) of hydroxylamine hydrochloride and of 7.72 g (0.0772 mol) of potassium bicarbonate in 8 ml of water is added, all at once, to a suspension of 10 g (0.0385 mol) of 4-(4-chlorophenoxy)-phenoxy-acetonitrile prepared as indicated in Example 29a), in 24 ml of n-butanol. The mixture is heated to the reflux temperature for 1 hour, the butanol is driven off, the residue is taken up in water and the insoluble matter is extracted with diethyl ether. The organic phase is washed with water, dried over dry sodium sulphate and evaporated, and the residue obtained is purified by washing with hot diisopropyl ether to give 10 g of brilliant white needles.

1. customprepared
2. temperatureThe mixture is heated to the reflux temperature for 1 hour
3. extractionthe insoluble matter is extracted with diethyl ether
4. washThe organic phase is washed with water
5. dry with materialdried over dry sodium sulphate
6. customevaporated
7. customthe residue obtained
8. customis purified
9. washby washing with hot diisopropyl ether