反应详情

A solution of 10.3 g of 3,3-bis(ethoxycarbonyl)-bicyclo[3.2.0]heptane in 68 ml of 16% potassium hydroxide in 1:1 methanol-water was refluxed for 16 hr under argon. The solvents were removed in vacuo and the residue dissolved in a minimum amount of water. The solution was acidified with concentrated hydrochloric acid and the precipitated acid isolated by vacuum filtration to yield 6.9 g of bicyclo[3.2.0]heptane-3,3-dicarboxylic acid as a white solid, mp 161°-170°.

1. customThe solvents were removed in vacuo
2. dissolutionthe residue dissolved in a minimum amount of water
3. customthe precipitated acid isolated by vacuum filtration