HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Bis(ethoxycarbonyl)bicyclo[3.2.0]heptane → Bicyclo[3.2.0]heptane-3,3-dicarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Bis(ethoxycarbonyl)bicyclo[3.2.0]heptane | HCID 21325433 | — |
| Reactant | Methanol--water (1/1) | HCID 22242641 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | Bicyclo[3.2.0]heptane-3,3-dicarboxylic acid | HCID 21325436 | 87.4% |
Reaction Steps
A solution of 10.3 g of 3,3-bis(ethoxycarbonyl)-bicyclo[3.2.0]heptane in 68 ml of 16% potassium hydroxide in 1:1 methanol-water was refluxed for 16 hr under argon. The solvents were removed in vacuo and the residue dissolved in a minimum amount of water. The solution was acidified with concentrated hydrochloric acid and the precipitated acid isolated by vacuum filtration to yield 6.9 g of bicyclo[3.2.0]heptane-3,3-dicarboxylic acid as a white solid, mp 161°-170°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04149017 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-c1f3a1a799a64fb08a85f59662c2de4f |
| Source note | uspto-grants-1979_04 |