反应详情

To a solution of sodium acetate (0.1 mole) in about 300 ml of glacial acetic acid is added about 0.05 mole of α-sulfo-α-aminoacetic acid hydrochloride. The solution is heated to reflux for 5 minutes, 2,5-dimethoxytetrahydrofuran (1 equivalent based on α-sulfo-α-aminoacetic acid hydrochloride) is added as quickly as possible, and the solution refluxed for an additional 2 minutes. The acetic acid is flash evaporated leaving a residue which is taken up in ethylacetate. The ethyl acetate is filtered, dried and evaporated to give α-sulfo-α-(1-pyrryl) acetic acid.

1. temperatureThe solution is heated
2. temperatureto reflux for 5 minutes
3. temperaturerefluxed for an additional 2 minutes
4. customevaporated
5. customleaving a residue which
6. filtrationThe ethyl acetate is filtered
7. customdried
8. customevaporated