Cyclohexyl isocyanate → 1-Cyclohexyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

HRID 263182Notes

Reaction equation

HRID 263182 reaction equation
Cl.[S:2]1[CH:6]=[CH:5][C:4]2[CH:7]([NH2:11])[CH2:8][CH2:9][CH2:10][C:3]1=2.[CH:12]1([N:18]=[C:19]=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>O1CCCC1>[CH:12]1([NH:18][C:19]([NH:11][CH:7]2[C:4]3[CH:5]=[CH:6][S:2][C:3]=3[CH2:10][CH2:9][CH2:8]2)=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 173886004,5,6,7-Tetrahydrobenzo[b]thiophen-4-amine hydrochloride

Product 1

HCID 203489831-Cyclohexyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a similar manner, as described in Example 1, 4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride is allowed to react with cyclohexyl isocyanate in dry tetrahydrofuran to afford 7 grams of 1-cyclohexyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, melting point 222° C. to 225° C.

Sources & evidence

ORD record
ord-4fb185a18e24446481528479fb3562a4
Source dataset
uspto-grants-1979_05
Patent number
US04156670

Reaction notes

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