N-methylhydroxylamine hydrochloride → 1-Hydroxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

HRID 263184Notes

Reaction equation

HRID 263184 reaction equation
Cl.[CH3:2][NH:3][OH:4].[S:5]1[CH:9]=[CH:8][C:7]2[CH:10]([N:14]=[C:15]=[O:16])[CH2:11][CH2:12][CH2:13][C:6]1=2>>[OH:4][N:3]([CH3:2])[C:15]([NH:14][CH:10]1[C:7]2[CH:8]=[CH:9][S:5][C:6]=2[CH2:13][CH2:12][CH2:11]1)=[O:16]

Participants

3

Reactant 2

HCID 77906N-methylhydroxylamine hydrochlorideHCID 205373014-Isocyanato-4,5,6,7-tetrahydro-1-benzothiophene

Product 1

HCID 203489841-Hydroxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

Procedure

In the manner described in Example 6, N-methylhydroxylamine hydrochloride and 4,5,6,7-tetrahydrobenzo[b]thien-4-yl isocyanate are allowed to react to afford 1-hydroxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, which is recrystallized from acetone-hexane-ether to give crystals, with melting point 98° C. to 102° C.

Workup

  1. customto react

Sources & evidence

ORD record
ord-e53f9eea52924b919eed8b394b02f99a
Source dataset
uspto-grants-1979_05
Patent number
US04156670

Reaction notes

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