HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-yl)acetamide | HCID 20348948 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride | HCID 20348970 | — |
Reaction Steps
The product from Example 23 (7.25 grams) is heated with 90 ml. of 1 N hydrochloric acid at reflux temperature for 8.5 hours and cooled. The mixture is diluted with water and extracted with methylene chloride. The aqueous layer is then evaporated to dryness using 2-propanol for facilitating removal of water. This gives 4.85 grams of 2-acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04156670 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-b3521a6f8f2e415b9f78c1b356a6abb0 |
| Source note | uspto-grants-1979_05 |