2-Methyl-1-benzofuran → HCID 21316615, compound

HRID 263288Notes

Reaction equation

HRID 263288 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[CH3:15][C:16]1[O:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[CH:17]=1.[Cl-].[Al+3].[Cl-].[Cl-]>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([C:17]2[C:18]3[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=3[O:20][C:16]=2[CH3:15])=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12]

Participants

4

Reactant 3

HCID 202632-Methyl-1-benzofuranHCID 30179793-(Aminosulfonyl)-4-chlorobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 21316615HCID 21316615, compound

Procedure

is obtained as described in Example 1 from 10.1 g 4-chloro-3-sulfamoylbenzoyl chloride and 5.8 g 2-methylbenzo[b]furan in the presence of 11.4 g aluminum chloride. After evaporation of the extraction agent, the residue is stirred with di-isopropyl ether, and the solids are filtered off. Colorless crystals, m.p. 183° C. (from methanol).

Workup

  1. customis obtained
  2. customAfter evaporation of the extraction agent
  3. filtrationthe solids are filtered off

Sources & evidence

ORD record
ord-6e6283f9cc9748389d130876c2b10792
Source dataset
uspto-grants-1979_05
Patent number
US04156732

Reaction notes

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