Skatole → HCID 21316622, compound

HRID 263299Notes

Reaction equation

HRID 263299 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[CH3:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[NH:18][CH:17]=1.[Cl-].[Al+3].[Cl-].[Cl-]>C(O)(C)C>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([C:17]2[NH:18][C:19]3[C:24]([C:16]=2[CH3:15])=[CH:23][CH:22]=[CH:21][CH:20]=3)=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12]

Participants

5

Reactant 3

HCID 6736SkatoleHCID 30179793-(Aminosulfonyl)-4-chlorobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 21316622HCID 21316622, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

is obtained as described in Example 10 (a) from 10.0 g 4-chloro-3-sulfamoylbenzoyl chloride and 5.1 g 3-methylindole in the presence of 10.4 g aluminum chloride. Colorless crystals from isopropanol, m.p. 205° C.

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-b993b4b7f4d044c8b0d60112c5d6f97e
Source dataset
uspto-grants-1979_05
Patent number
US04156732

Reaction notes

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