反应详情

2 g KOH are dissolved in 50 ml methanol, a solution of 5.4 g 2-hydroxy-3-methoxybenzaldehyde is added and subsequently a suspension of 10 g 2-bromo-4'-chloro-3'-nitroacetophenone in 75 ml methanol. The batch is refluxed for 6 hours, agitation is continued overnight at room temperature, and the crystals are suction-filtered. M.p. 136° C. (from ethyl acetate).

1. temperatureThe batch is refluxed for 6 hours
2. filtrationthe crystals are suction-filtered