反应详情

温度

50 °C

Ethyl 3-ketohexanoate 50 g (0.32 mol), Raney nickel 10 g and tetrahydrofuran 500 ml were mixed, and the mixture was reacted with stirring in an autoclave at a temperature of 50° C. and a hydrogen pressure of 5 kg/cm2 for 30 hours. After removing the Raney nickel from the reactant by filtration, the filtrate was concentrated and distilled under reduced pressure to obtain racemic ethyl 3-hydroxyhexanoate 42 g (0.26 mol, 85% )

1. customthe mixture was reacted
2. customAfter removing the Raney nickel from the reactant
3. filtrationby filtration
4. concentrationthe filtrate was concentrated
5. distillationdistilled under reduced pressure