反应详情

Pyrazinecarboxylic acid (3.7 g, 30 mmol), benzene (25 mL) and thionyl chloride (15 mL) were added into a 100 mL round bottom flask. The reaction mixture was heated under reflux for two hours after which time benzene and excess thionyl chloride were removed by distillation. The dark red crude pyrazinoyl chloride was purified by sublimation under vacuum at a bath temperature of 50°-60° C. to give colorless crystals that weighed 3.2 g (74% yield).

1. temperatureThe reaction mixture was heated
2. customwere removed by distillation
3. customThe dark red crude pyrazinoyl chloride was purified by sublimation under vacuum at a bath temperature of 50°-60° C.
4. customto give colorless crystals that