HCID 14023265, compound → HCID 11355491, compound

HRID 263443Notes

Reaction equation

HRID 263443 reaction equation
C(OC([NH:11][C@@H:12]([CH:17]([CH3:19])[CH3:18])[C:13](=[O:16])[CH2:14][CH3:15])=O)C1C=CC=CC=1>O1CCCC1.[Pd]>[NH2:11][C@@H:12]([CH:17]([CH3:19])[CH3:18])[C:13](=[O:16])[CH2:14][CH3:15]

Participants

4

Reactant 1

HCID 14023265HCID 14023265, compound

Product 1

HCID 11355491HCID 11355491, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

4-(S)-Benzyloxycarbonylamino-5-methyl-3-oxohexane (61 mg), prepared in Referential Example 15, was dissolved in tetrahydrofuran (2.0 ml) and catalytically reduced by stirring for 40 minutes under an atmosphere of hydrogen in the presence of 10% palladium on charcoal (6 mg). After the catalyst had been filtered off, the filtrate was concentrated under reduced pressure to yield 4-(S)-amino-5-methyl-3-oxohexane as a crude product.

Workup

  1. filtrationAfter the catalyst had been filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0e8cbc08e192467daeeded7fd946b2c1
Source dataset
uspto-grants-1997_07
Patent number
US05643908

Reaction notes

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