tert-Butyl bromoacetate → HCID 10936768, compound

HRID 263444Notes

Reaction equation

HRID 263444 reaction equation
[CH:1]([C@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10](=[O:16])[CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])([CH3:3])[CH3:2].Br[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>>[CH:1]([C@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10](=[O:16])[C@@H:11]([CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:12][CH:13]([CH3:15])[CH3:14])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 54390831HCID 54390831, compound

Product 1

HCID 10936768HCID 10936768, compound

Procedure

Following the procedure described in Referential Example 4, but using 4-(S)-isopropyl-3-(1-oxo-4-methylpentyl)-2-oxazolidinone (5.17 g), prepared in Referential Example 38, and tert-butyl bromoacetate (18.5 ml) as starting materials, the desired compound (6.16 g), having a m.p. of 143°-144° C. after recrystallization from aqueous methanol, was obtained.

Sources & evidence

ORD record
ord-c04fe0a0a9e64dd1af2f3ca1e1af9609
Source dataset
uspto-grants-1997_07
Patent number
US05643908

Reaction notes

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