Hydrochloric Acid → HCID 19038199, compound

HRID 263469Notes

Reaction equation

HRID 263469 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([NH:11][C:12](=[O:23])[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[C:17]([NH2:22])[CH:16]=2)[CH:2]=1.[ClH:24]>CO.O1CCOCC1>[ClH:24].[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([NH:11][C:12](=[O:23])[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[C:17]([NH2:22])[CH:16]=2)[CH:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 15390019HCID 15390019, compound

Product 1

HCID 19038199HCID 19038199, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 1 g of N-(3-quinolyl)-3-(3,4-diaminophenyl)propionamide (prepared as described in Example 34) in 20 ml of methanol were added 5 ml of 4N hydrogen chloride in dioxane with ice-cooling, and the solvent was distilled off. The residue was recrystallized from a mixture of methanol and ether to afford 0.7 g of the desired compound, melting at 246°-247° C.

Workup

  1. temperaturecooling
  2. distillationthe solvent was distilled off
  3. customThe residue was recrystallized from a mixture of methanol and ether

Sources & evidence

ORD record
ord-dc24780620064c2282f78134883c034e
Source dataset
uspto-grants-1997_07
Patent number
US05643925

Reaction notes

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