HCID 19037671, compound → HCID 19037623, compound

HRID 263488Notes

Reaction equation

HRID 263488 reaction equation
[C:1]([N:5]([N:9]1[CH:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:14][CH:13]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:12][CH:11]([NH:28]C(=O)C(N)CC2C=CC=CC=2)[C:10]1=[O:40])[C:6](=[O:8])[CH3:7])([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C>[C:1]([N:5]([N:9]1[CH:15]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:14][CH:13]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:12][CH:11]([NH2:28])[C:10]1=[O:40])[C:6](=[O:8])[CH3:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 1

HCID 19037671HCID 19037671, compound

Product 1

HCID 19037623HCID 19037623, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared as above from 1-(N-t-butylacetamido)-3-(2-amino-3-phenylpropionamido)-5,7-diphenylhexahydroazepin-2-one (less polar isomer) as an oil in 92% yield, αD =+3.21° (c=0.8, ethyl acetate). The 1H-NMR spectrum matches that of the racemate.

Sources & evidence

ORD record
ord-aaa8e01f8a8c4a3eb9c986d6e44557fc
Source dataset
uspto-grants-1997_07
Patent number
US05643904

Reaction notes

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