反应详情

A solution of o-chlorobenzoyl chloride (1.93 g.) and 4-ethyl-4-oxazolin-2-one (1.13 g.) in 30 ml. of benzene is cooled to 10° C. and reacted with 1.21 g. of triethylamine dissolved in 5 ml. of benzene. The reaction mixture is stirred at room temperature for 1 hour. The excess triethylamine and benzene is removed under reduced pressure to leave a light yellow oil (2.4 g.) which is triturated with ethanol whereupon a crystalline solid separates. The solid is removed and washed with a small amount of cold ethanol and dried. Yield 0.3 g.; m.p. 110°-112° C.

1. customreacted with 1.21 g
2. customThe excess triethylamine and benzene is removed under reduced pressure
3. customto leave a light yellow oil (2.4 g.) which
4. customis triturated with ethanol whereupon a crystalline solid separates
5. customThe solid is removed
6. washwashed with a small amount of cold ethanol
7. customdried