1,3-Dichloroacetone → 4-(Chloromethyl)-2-(3,4-dimethoxyphenyl)-1,3-thiazole

Beteiligte Stoffe

Reaktionsschritte

1.5 g of 1,3-dichloroacetone and 2.3 g of 3,4-dimethoxythiobenzamide were suspended in 100 ml of ethanol. The suspension was heated for 3 hours to complete the reaction. The solvent was removed by distillation. The residue was purified by silica gel column chromatography to obtain 1.86 g of 2-(3,4-dimethoxyphenyl)-4-chloromethylthiazole as a colorless viscous oil.

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