反应详情

1.5 g of 1,3-dichloroacetone and 2.3 g of 3,4-dimethoxythiobenzamide were suspended in 100 ml of ethanol. The suspension was heated for 3 hours to complete the reaction. The solvent was removed by distillation. The residue was purified by silica gel column chromatography to obtain 1.86 g of 2-(3,4-dimethoxyphenyl)-4-chloromethylthiazole as a colorless viscous oil.

1. temperatureThe suspension was heated for 3 hours
2. customthe reaction
3. customThe solvent was removed by distillation
4. customThe residue was purified by silica gel column chromatography