Hydrazine hydrate (1:1) → HCID 18707265, compound

HRID 263580Notes

Reaction equation

HRID 263580 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH3:24])=[C:18]([O:25][CH2:26][CH3:27])[CH:17]=2)[S:9][C:10]=1[C:11](OCC)=[O:12])=O)C.O.[NH2:29][NH2:30]>C(O)C>[CH2:26]([O:25][C:18]1[CH:17]=[C:16]([C:8]2[S:9][C:10]3[C:11](=[O:12])[NH:30][NH:29][C:4](=[O:3])[C:6]=3[N:7]=2)[CH:21]=[CH:20][C:19]=1[O:22][CH2:23][CH3:24])[CH3:27]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18707171HCID 18707171, compound

Product 1

HCID 18707265HCID 18707265, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
130 °C

Procedure

In 4 ml of ethanol was suspended 1 g of 4,5-diethoxycarbonyl-2-(3,4-diethoxyphenyl)thiazole. Thereto was added 2 ml of hydrazine hydrate. The mixture was sealed in a tube and heated at 130° C. for 48 hours. After cooling, the resulting crystals were collected by filtration, washed with ethanol, dried and recrystallized from dimethylformamide to obtain 220 mg of 2-(3,4-diethoxyphenyl)-5,6-dihydrothiazolo[4,5-d]pyridazine-4,7-dione.

Workup

  1. customThe mixture was sealed in a tube
  2. temperatureAfter cooling
  3. filtrationthe resulting crystals were collected by filtration
  4. washwashed with ethanol
  5. customdried
  6. customrecrystallized from dimethylformamide

Sources & evidence

ORD record
ord-832be3df579f40fb897f0809055a1f30
Source dataset
uspto-grants-1997_07
Patent number
US05643932

Reaction notes

Loading…