m-Chloroperbenzoic acid → HCID 54399296, compound

HRID 263624Notes

Reaction equation

HRID 263624 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[C:7](=[CH:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([CH3:21])=[O:20])=[CH:15][CH:14]=1)[C:6]([CH3:22])=[C:5]2[CH2:23][C:24]([OH:26])=[O:25].ClC1C=CC=C(C(OO)=[O:35])C=1>CC(C)=O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[C:7](=[CH:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([CH3:21])(=[O:35])=[O:20])=[CH:15][CH:14]=1)[C:6]([CH3:22])=[C:5]2[CH2:23][C:24]([OH:26])=[O:25]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 54032229HCID 54032229, compound

Product 1

HCID 54399296HCID 54399296, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To 5,6-difluoro-2-methyl-1-(ρ-methylsulfinylbenzylidene)-indene-3-aceticacid (0.005 mole) in acetone (15 ml.) is added, slowly with stirring, m-chloroperbenzoic acid (0.005 mole). The mixture is heated and evaporated to near dryness at 40°. The solid is washed with boiling water (4×50 ml.) and dried yielding 5,6-difluoro-2-methyl-1-(ρ-methylsulfonylbenzylidene)-indene-3-acetic acid, M.P. 228°-230°. (R1 =hydrogen; R2 =CH3 ; R3 =5-fluoro; R4 =6-fluoro; R5 =CH3 --SO2 --).

Workup

  1. temperatureThe mixture is heated
  2. customevaporated
  3. customat 40°
  4. washThe solid is washed with boiling water (4×50 ml.)
  5. customdried

Sources & evidence

ORD record
ord-452a3c48ba9c42cea004229928dd9ac8
Source dataset
uspto-grants-1997_07
Patent number
US05643959

Reaction notes

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