反应详情

A solution of N-Methyl-N-[2-(2,4,6-trimethylphenyl)-2-cyanovinyl]-glycine ethyl ester (6.8 g, 24 mmol) in 0.28M ethanolic sodium ethoxide (100 mL) was heated at 70° C. for 6 h. The reaction was cooled and evaporated in vacuo. The residue was treated with water and neutralized with acetic acid and the product was extracted with ethyl acetate. After drying the solvent was removed in vacuo to afford 3-Amino-2-ethoxycarbonyl-1-methyl-4-(2,4,6-trimethylphenyl)-1H-pyrrole as a yellow oil.

1. temperatureThe reaction was cooled
2. customevaporated in vacuo
3. additionThe residue was treated with water and neutralized with acetic acid
4. extractionthe product was extracted with ethyl acetate
5. customAfter drying the solvent
6. customwas removed in vacuo