反应详情

Analogously to Example 1i), 4.5 g (10.8 mmol) of 5(S)-[1(S)-(Boc-amino)-2-phenylethyl]-3(R)-(o-fluorophenylmethyl)-dihydrofuran-2-(3H)-one in 170 ml of dimethoxyethane are hydrolysed with 43.5 ml of 1M lithium hydroxide solution. The evaporation residue of the reaction mixture is poured onto a mixture of ice, 120 ml of sat. ammonium chloride solution and 240 ml of 10% citric acid solution, and extracted with 3 portions of methylene chloride. The organic phases are washed with water and brine, dried over Na2SO4 and concentrated by evaporation: tRet (I)=14.5 min.

1. extractionextracted with 3 portions of methylene chloride
2. washThe organic phases are washed with water and brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated by evaporation
5. customtRet (I)=14.5 min.