Hydrogen Bromide → HCID 19035805, compound

HRID 263852Notes

Reaction equation

Cl.[CH2:2]([NH:4][C@@H:5]1[C:10]2[CH:11]=[C:12]([S:14]([NH2:17])(=[O:16])=[O:15])[S:13][C:9]=2[S:8](=[O:19])(=[O:18])[N:7]([CH2:20][CH2:21][CH2:22]OC)[CH2:6]1)[CH3:3].[BrH:25]>>[Br:25][CH2:22][CH2:21][CH2:20][N:7]1[CH2:6][CH:5]([NH:4][CH2:2][CH3:3])[C:10]2[CH:11]=[C:12]([S:14]([NH2:17])(=[O:16])=[O:15])[S:13][C:9]=2[S:8]1(=[O:19])=[O:18]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 11711447Brinzolamide hydrochloride

Product 1

HCID 19035805HCID 19035805, compoundYield 96%

Procedure

A stirred solution of (+)-(R)-4-ethylamino-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno-[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide hydrochloride (4.5 g, 110.7 mmol) in 48% HBr (20.0 mL) was heated at 80° C. for 72 h. The reaction mixture was concentrated in vacuo at 60° C. bath temperature to give a pale tan solid (4.8 g, 96%).

Workup

concentrationThe reaction mixture was concentrated in vacuo at 60° C. bath temperature

Sources & evidence

ORD record: ord-27da5bc1686c463484aacbeace1a6d35
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05646142

Reaction notes

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