Sodium Bicarbonate → Propyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

HRID 26388Notes

Reaction equation

HRID 26388 reaction equation
[CH:1]1([CH3:13])[CH2:6][CH2:5][CH:4]([CH:7]([CH3:9])[CH3:8])[CH:3]([C:10](Cl)=[O:11])[CH2:2]1.Cl.[CH2:15]([O:18][C:19](=[O:22])[CH2:20][NH2:21])[CH2:16][CH3:17].C(=O)(O)[O-].[Na+]>>[CH2:15]([O:18][C:19](=[O:22])[CH2:20][NH:21][C:10]([CH:3]1[CH:4]([CH:7]([CH3:9])[CH3:8])[CH2:5][CH2:6][CH:1]([CH3:13])[CH2:2]1)=[O:11])[CH2:16][CH3:17]

Participants

4

Reactant 3

HCID 516892Sodium BicarbonateHCID 2759254Propyl aminoacetate hydrochlorideHCID 13734319Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-

Product 1

HCID 56843152Propyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

Procedure

Following the procedure of Example 2 p-menth-3-oyl chloride (2.0 g., 0.01 moles), was reacted with glycine propyl ester hydrochloride (1.5 g., 0.01 moles) and sodium bicarbonate (1.6 g., 0.02 moles). The crude product was distilled b.p. 170°/0.1 mm. (After distillation the product rapidly solidifies). (Found, C: 68.2; H: 1016; N: 5.0. C16H29NO3 requires, C: 67.8; H: 10.6; N: 4.9.)

Workup

  1. distillationThe crude product was distilled b.p. 170°/0.1 mm
  2. distillation(After distillation the product

Sources & evidence

ORD record
ord-1481e580750f450787bfa5f594e59f0b
Source dataset
uspto-grants-1979_04
Patent number
US04150052

Reaction notes

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