反应详情

8-(2-(p-Chlorophenyl)-2-oxoethoxy)-2-methylquinoline (12a) was prepared from 2-bromo-4'-chloroacetophenone by the same procedure as 10a in 64% yield. mp: 112°-113° C.; 1H-NMR (CDCl3): δ2.77 (s, 3H, 2-CH3), 5.56 (s, 2H, OCH2), 6.94-8.12 (m, 8H, Ar--H), 7.31 (d, 1H, 3-H), 8.00 (d, 1H, 4-H).