HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Chlorophenacyl bromide → 8-(2-(p-Chlorophenyl)-2-oxoethoxy)-2-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Chlorophenacyl bromide | HCID 68303 | — |
| Reactant | 2-Methyl-8-(2-oxopropoxy)quinoline | HCID 10727414 | — |
| Product | 8-(2-(p-Chlorophenyl)-2-oxoethoxy)-2-methylquinoline | HCID 10733843 | 64% |
Reaction Steps
8-(2-(p-Chlorophenyl)-2-oxoethoxy)-2-methylquinoline (12a) was prepared from 2-bromo-4'-chloroacetophenone by the same procedure as 10a in 64% yield. mp: 112°-113° C.; 1H-NMR (CDCl3): δ2.77 (s, 3H, 2-CH3), 5.56 (s, 2H, OCH2), 6.94-8.12 (m, 8H, Ar--H), 7.31 (d, 1H, 3-H), 8.00 (d, 1H, 4-H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646164 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-1ab71246efad4d469f1285e4c41b1189 |
| Source note | uspto-grants-1997_07 |