反应详情

A solution of 2-chlorobenzoxazole (12.78 g) in dry tetrahydrofuran (50 ml) was added, over 10 minutes, to a stirred, ice-cooled solution of ethanolamine (15.3 g) in dry tetrahydrofuran (400 ml). The mixture was heated at reflux overnight, cooled, and the solvent evaporated. The residue was partitioned between water (500 ml) and dichloromethane (500 ml), and the resulting white solid filtered off, washed with dichloromethane and dried in vacuo to afford the title compound m.p. 162°-4° C.

1. temperatureThe mixture was heated
2. temperatureat reflux overnight
3. temperaturecooled
4. customthe solvent evaporated
5. customThe residue was partitioned between water (500 ml) and dichloromethane (500 ml)
6. filtrationthe resulting white solid filtered off
7. washwashed with dichloromethane
8. customdried in vacuo