Hydrochloric Acid → HCID 21846489, compound

HRID 264018Notes

Reaction equation

HRID 264018 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13](=[O:14])[C:12]3([CH2:19][CH2:18][S:17][CH2:16][CH2:15]3)[N:11]([CH2:20][CH2:21][CH2:22][C:23]([O:25]CC)=[O:24])[C:10]2=[O:28])=[CH:5][C:4]=1[C:29]([F:32])([F:31])[F:30])#[N:2].[OH-].[Na+].Cl>CO>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13](=[O:14])[C:12]3([CH2:19][CH2:18][S:17][CH2:16][CH2:15]3)[N:11]([CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:10]2=[O:28])=[CH:5][C:4]=1[C:29]([F:30])([F:32])[F:31])#[N:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21846472HCID 21846472, compound

Product 1

HCID 21846489HCID 21846489, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using the procedure of Example 7, 440 mg of the product of Example 18, 20 ml of methanol and 2 ml of 2N sodium hydroxide were reacted and the mixture was stirred for 3 hours and 30 minutes at ambient temperature. 3 ml of 2N hydrochloric acid were added and purification was carried out on silica with methylene chloride-methanol: 95-5 as eluant to obtain 346 mg of the expected product (white crystals) melting at 197°-198° C.

Workup

  1. customwere reacted
  2. custompurification

Sources & evidence

ORD record
ord-5ba5d1b2047747e683867c127c10f5ed
Source dataset
uspto-grants-1997_07
Patent number
US05646172

Reaction notes

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