反应详情

The mixture of 22.1 g of 3-(2-piperidinopropyl)-4-(4-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone and 128 ml of 48% hydrobromic acid is stirred under reflux for six hours. It is cooled, basified with concentrated ammonia and extracted with chloroform. The extract is dried, evaporated, the residue crystallized from diethyl ether and recrystallized from acetone, to yield the 3-(2-piperidinopropyl)4-(4-hydroxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone melting at 178°-181°.

1. temperatureunder reflux for six hours
2. temperatureIt is cooled
3. extractionextracted with chloroform
4. customThe extract is dried
5. customevaporated
6. customthe residue crystallized from diethyl ether
7. customrecrystallized from acetone