反应详情

254 mg of N-[2-(4,5-dihydro-8-methoxy-1H-benz[g]indol-1-yl)ethyl]-acetamide were dissolved in 10 ml of dioxane under argon, 238 mg of DDQ were added and the mixture was heated to reflux for 1 hour. Separated crystals were removed by filtration, the filtrate was evaporated and the residue was chromatographed on 50 g of silica gel with methylene chloride/acetone 9:1. 211 mg (83%) of N-[2-(8-methoxy-1H-benz[g]indol-1-yl)ethyl]-acetamide were obtained as a light yellowish solid. Tlc (silica gel): Rf=0.25 (methylene chloride/acetone 9:1).

1. temperaturethe mixture was heated
2. temperatureto reflux for 1 hour
3. customSeparated crystals
4. customwere removed by filtration
5. customthe filtrate was evaporated
6. customthe residue was chromatographed on 50 g of silica gel with methylene chloride/acetone 9:1