Phenyl isocyanate → HCID 44289218, compound

HRID 264702Notes

Reaction equation

HRID 264702 reaction equation
[CH2:1]([C@@H:8]1[CH2:13][C@@H:12]([NH2:14])[CH2:11][CH2:10][N:9]1[C:15](=[O:24])[C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([Cl:23])[CH:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]1([N:31]=[C:32]=[O:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:1]([C@@H:8]1[CH2:13][C@@H:12]([NH:14][C:32](=[O:33])[NH:31][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:11][CH2:10][N:9]1[C:15](=[O:24])[C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([Cl:23])[CH:17]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 53839030(2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine

Product 1

HCID 44289218HCID 44289218, compound

Procedure

200 mg (0.551 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine are reacted with 85 mg (0.716 mmol) of phenyl isocyanate in analogy to Example 16a. The title compound ##STR97## is obtained as white foam (160 mg, 60%). TLC:tolnene/ethyl acetate (1:1) Rf =0.40, FD-MS:M+ =481, 483; IR:1600-1690 cm-1.

Sources & evidence

ORD record
ord-3bd353335a7e4c0fb4497c5f273e7be2
Source dataset
uspto-grants-1997_07
Patent number
US05646144

Reaction notes

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