HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 2'-O-Pentyluridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 1-Bromopentane | HCID 8057 | — |
| Reactant | 2',3'-O-dibutylstannyleneuridine | HCID 131720090 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2'-O-Pentyluridine | HCID 15546014 | — |
Reaction Steps
Utilizing the procedures of Examples 50 and 51, 2',3'-O-dibutylstannylene uridine (19.1 g) was treated with bromopentane (7 ml, 1.3 eq.) and sodium iodide (4.5 g) in DMF (90 ml). Purification on a silica gel column utilizing MeOH/CH2Cl2 5%→10% yielded the a mixture of 2' and 3' isomers of the product as a dark oil (9.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646265 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-87c91f2be3eb429faabfa16d481a058a |
| Source note | uspto-grants-1997_07 |