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HRID264731

反应详情

EQUATION

反应方程式

HRID 264731 的结构方程式

REACTANTS

反应物

3
结构：[I-].[Na+]
HCID5238

Sodium Iodide

INa

结构：CCCCCBr
HCID8057

1-Bromopentane

C5H11Br

结构：CCCCO[C@@H]1[C@@H]([C](O)=[SnH2])O[C@@H](n2ccc(=O)[nH]c2=O)[C@@]1(O)CCCC
HCID131720090

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1ccc(=O)[nH]c1=O
HCID15546014

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Utilizing the procedures of Examples 50 and 51, 2',3'-O-dibutylstannylene uridine (19.1 g) was treated with bromopentane (7 ml, 1.3 eq.) and sodium iodide (4.5 g) in DMF (90 ml). Purification on a silica gel column utilizing MeOH/CH2Cl2 5%→10% yielded the a mixture of 2' and 3' isomers of the product as a dark oil (9.8 g).

WORKUP

后处理

  1. customPurification on a silica gel column
  2. customyielded