2-Fluorophenyltributyltin → 3,4-Dihydro-7-fluoro-6-(2-fluorophenyl)-1(2H)-naphthalenone

HRID 264775Notes

Reaction equation

HRID 264775 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:12])=[CH:4][C:3]=1OS(C(F)(F)F)(=O)=O.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[Sn](CCCC)(CCCC)CCCC>>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:12])=[CH:4][C:3]=1[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[F:21]

Participants

3

Reactant 2

HCID 150471822-FluorophenyltributyltinHCID 190368843,4-dihydro-7-fluoro-6-trifluoromethylsulfonyloxy-1(2H)-naphthalenone

Product 1

HCID 190368793,4-Dihydro-7-fluoro-6-(2-fluorophenyl)-1(2H)-naphthalenoneYield 53.2%

Procedure

Using 1.50 g (4.80 mmol) of 3,4-dihydro-7-fluoro-6-trifluoromethylsulfonyloxy-1(2H)-naphthalenone and 2.22 g (5.78 mmol) of 2-fluorophenyltributyltin, the same reaction as described in Reference Example 1 was carried out to obtain 0.66 g of the above-mentioned compound (yield 53%).

Workup

  1. customthe same reaction

Sources & evidence

ORD record
ord-47c62c4d73124b5c971d0d5371738cdd
Source dataset
uspto-grants-1997_07
Patent number
US05646283

Reaction notes

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