Tributyl(4-fluorophenyl)stannane → 3,4-Dihydro-7-fluoro-6-(4-fluorophenyl)-1(2H)-naphthalenone

HRID 264776Notes

Reaction equation

HRID 264776 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:12])=[CH:4][C:3]=1OS(C(F)(F)F)(=O)=O.[F:21][C:22]1[CH:27]=[CH:26][C:25]([Sn](CCCC)(CCCC)CCCC)=[CH:24][CH:23]=1>>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:12])=[CH:4][C:3]=1[C:25]1[CH:26]=[CH:27][C:22]([F:21])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 2737524Tributyl(4-fluorophenyl)stannaneHCID 190368843,4-dihydro-7-fluoro-6-trifluoromethylsulfonyloxy-1(2H)-naphthalenone

Product 1

HCID 190368933,4-Dihydro-7-fluoro-6-(4-fluorophenyl)-1(2H)-naphthalenoneYield 61.3%

Procedure

Using 1.50 g (4.80 mmol) of 3,4-dihydro-7-fluoro-6-trifluoromethylsulfonyloxy-1(2H)-naphthalenone and 1.85 g (4.80 mmol) of 4-fluorophenyltributyltin, the same reaction as described in Reference Example 1 was carried out to obtain 0.76 g of the above-mentioned compound (yield 61%).

Workup

  1. customthe same reaction

Sources & evidence

ORD record
ord-abbaf749185545a2b6fa2ae9729af714
Source dataset
uspto-grants-1997_07
Patent number
US05646283

Reaction notes

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