Hydrochloric Acid → HCID 9879640, compound

HRID 264825Notes

Reaction equation

HRID 264825 reaction equation
[F:1][CH2:2][C:3]1([CH2:22][F:23])[CH:8]=[C:7]([C:9]([O:11]CC)=[O:10])[C:6]2[CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=[CH:17][C:5]=2[O:4]1.[OH-].[K+].Cl>C(O)C>[F:23][CH2:22][C:3]1([CH2:2][F:1])[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[C:6]2[CH:14]=[C:15]([C:18]([F:21])([F:19])[F:20])[CH:16]=[CH:17][C:5]=2[O:4]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19037095ethyl 2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carboxylate

Product 1

HCID 9879640HCID 9879640, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.51 g of ethyl 2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carboxylate, 0.13 g of potassium hydroxide and 10 ml of ethyl alcohol was stirred at room temperature for 2 hours. Ice water and hydrochloric acid were added to the reaction mixture, and the precipitated crystals were separated by filtration to obtain 0.43 g of 2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carboxylic acid.

Workup

  1. customthe precipitated crystals were separated by filtration

Sources & evidence

ORD record
ord-527ec59873e44f8abe5764e934f45ec4
Source dataset
uspto-grants-1997_07
Patent number
US05646310

Reaction notes

Loading…