Hydrochloric Acid → HCID 57480419, compound

HRID 264938Notes

Reaction equation

HRID 264938 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][NH:9][C:10](=[O:47])[C@H:11]([CH:44]([CH3:46])[CH3:45])[CH2:12][C@H:13]([OH:43])[C@@H:14]([NH:35]C(OC(C)(C)C)=O)[CH2:15][C@@H:16]([CH:32]([CH3:34])[CH3:33])[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH2:27][CH2:28][CH2:29][O:30][CH3:31])[CH:19]=2)[CH2:3][CH2:2]1.[ClH:48]>O1CCOCC1>[ClH:48].[ClH:48].[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][NH:9][C:10](=[O:47])[C@H:11]([CH:44]([CH3:46])[CH3:45])[CH2:12][C@H:13]([OH:43])[C@@H:14]([NH2:35])[CH2:15][C@@H:16]([CH:32]([CH3:33])[CH3:34])[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH2:27][CH2:28][CH2:29][O:30][CH3:31])[CH:19]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23625188HCID 23625188, compound

Product 1

HCID 57480419HCID 57480419, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

3.09 g of 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-2(S),7(S)-diisopropyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid N-(2-morpholinoethyl)amide are dissolved in 40 ml of 4N hydrochloric acid in dioxane at 0° C. and the solution is stirred at 0° C. for 2 hours. The reaction mixture is lyophilised and the title compound is obtained: Rf (dichloromethane/methanol=8:2)=0.27; HPLC Rt =9.52 minutes; HR FAB-MS (M+H)+ =566.

Sources & evidence

ORD record
ord-86dcb605867f42ffa8b4e51be90a0219
Source dataset
uspto-grants-1997_07
Patent number
US05646143

Reaction notes

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