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HRID264948

反应详情

EQUATION

反应方程式

HRID 264948 的结构方程式

REACTANTS

反应物

4
结构：ClCCl
HCID6344

Dichloromethane

CH2Cl2

结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：COCCCOc1cc(C[C@@H](C[C@H](NC(=O)OC(C)(C)C)[C@@H](O)C[C@H](C(=O)NC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC
HCID23627070

未命名化合物

PRODUCTS

生成物

1
结构：COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC.Cl
HCID23626424

未命名化合物

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

1.5 ml of trifluoroacetic acid are added to 56 mg of 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-2(S),7(S)-diisopropyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid [N-(1-carbamoyl-1-methyl-ethyl)]-amide in 1.5 ml of dichloromethane at 0° C. The mixture is stirred for a further 30 minutes at 0° C. The reaction mixture is poured onto cooled 1N sodium hydroxide and the product is extracted repeatedly with dichloromethane. The organic phases are dried, and ethereal hydrochloric acid is added. Concentration by evaporation yields the title compound: Rf (dichloromethane/methanol=8:2)=0.30; HPLC Rf =11.25; FAB-MS (M+H)+ =538.

WORKUP

后处理

  1. additionThe reaction mixture is poured
  2. extractionthe product is extracted repeatedly with dichloromethane
  3. customThe organic phases are dried
  4. additionethereal hydrochloric acid is added
  5. concentrationConcentration
  6. customby evaporation