Sulfuric Acid → 11-Methyl-3-methylthio-11H-s-triazolo[3,4-b][3]benzazepine

HRID 26506Notes

Reaction equation

HRID 26506 reaction equation
C(O[CH:4](OCC)[CH2:5][N:6]1[C:10]([S:11][CH3:12])=[N:9][N:8]=[C:7]1[CH:13]([CH3:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)C.S(=O)(=O)(O)O>>[CH3:20][CH:13]1[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH:4]=[CH:5][N:6]2[C:10]([S:11][CH3:12])=[N:9][N:8]=[C:7]12

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 213235304-(2,2-diethoxyethyl)-3-(alpha-methylbenzyl)-5-methylthio-4H-1,2,4-triazole

Product 1

HCID 2132353411-Methyl-3-methylthio-11H-s-triazolo[3,4-b][3]benzazepine

Procedure

12.5 g of the 4-(2,2-diethoxyethyl)-3-(α-methylbenzyl)-5-methylthio-4H-1,2,4-triazole prepared in Reference Example 10 was added to cold concentrated sulfuric acid and the cyclization reaction mixture was treated by a procedure similar to that described in Example 2. By the above procedure was obtained 11-methyl-3-methylthio-11H-s-triazolo[3,4-b][3]benzazepine as an oil.

Workup

  1. customthe cyclization reaction mixture
  2. additionwas treated by a procedure similar to

Sources & evidence

ORD record
ord-b0c3c4d87edd4dd0a28571c33c0228a2
Source dataset
uspto-grants-1979_04
Patent number
US04150139

Reaction notes

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