Sulfuric Acid → 11-Methyl-3-methylthio-11H-s-triazolo[3,4-b][3]benzazepine

Participants

Reaction Steps

12.5 g of the 4-(2,2-diethoxyethyl)-3-(α-methylbenzyl)-5-methylthio-4H-1,2,4-triazole prepared in Reference Example 10 was added to cold concentrated sulfuric acid and the cyclization reaction mixture was treated by a procedure similar to that described in Example 2. By the above procedure was obtained 11-methyl-3-methylthio-11H-s-triazolo[3,4-b][3]benzazepine as an oil.

Provenance & Evidence