HRID265089

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9906257

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate

C18H19BrO2

HCID10286015

Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate

C12H18N2O4

HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

PRODUCTS

生成物

结构：CCCc1nc(C(=O)OCC)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1

HCID10768304

未命名化合物

收率 89.4%

PROCEDURE

实验过程

Following a procedure similar to that described in Example 1(a), but using 9.0 g of diethyl 2-propylimidazole-4,5-dicarboxylate (prepared as described in Preparation 12), 12.3 g of t-butyl 4'-bromomethylbiphenyl-2-carboxylate and 4.1 g of potassium t-butoxide as a base. 16.47 g of the title compound were obtained as a viscous oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a27ac930d3e64f438cefabba153d70b7
来源数据集: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05646171
来源说明: uspto-grants-1997_07

反应 SMILES

[CH2:1]([C:4]1[NH:5][C:6]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:8]=1)[CH2:2][CH3:3].Br[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[C:28]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=[CH:29][CH:30]=[CH:31][CH:32]=2)=[CH:23][CH:22]=1.CC(C)([O-])C.[K+]>>[C:36]([O:35][C:33]([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=1[C:24]1[CH:25]=[CH:26][C:21]([CH2:20][N:8]2[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:6]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:5]=[C:4]2[CH2:1][CH2:2][CH3:3])=[CH:22][CH:23]=1)=[O:34])([CH3:39])([CH3:38])[CH3:37]